Staff Background
The Biotech Advisor
Biotechnology Consulting Services
Martin A. Winkler, Ph.D.
PROFESSIONAL EXPERIENCE

Principal Scientist
1999  to Feb.  2005--Abbott Laboratories, Diagnostics Division
Core R&D Analytical Chemistry—Supervised a group of  bioanalytical Ph.D  scientists.  Responsible for macromolecular analysis (proteins, peptides, glycoconjugates, polymers) and bioanalytical methods development. .

Senior Research Biochemist
1997- 1998—Abbott Laboratories,  Diagnostics Division
ADD  Analytical Research--Protein characterization and methods development for proteins in immunoassays.  Analysis by mass spectrometry, capillary electrophoresis, HPLC, and other protein bioanalytical techniques.

Senior Research Analytical Chemist
1995-1996--Abbott Pharmaceutical Products Division
Analytical Research and Development—Analytical methods development for Recombinant Pro-Urokinase and other recombinant proteases and protein drug candidates.   All work done in a cGMP environment.

Senior Research Biochemist
1989-1994--Abbott Diagnostics Division
Lead Biochemist—1989-1993.  Antigen identification, purification, and characterization  for Abbott Chagas Antibody EIA 510(k) submission.   Product launched 7/95.
Developed  Chagas Radioimmunoprecipitation assay for seroconfirmation.
Developed Chagas confirmatory EIA for R & D use.

Lead Scientist— 1994.   Recombinant antigen identification, purification, and characterization for CBER-approvable Chagas’ disease blood screens.

Lead Biochemist-1995.   Maldi-TOF mass spectrometry and capillary electrophoresis methods for recombinant protein characterization.

Staff Scientist
1987-1989 --Biotherapeutics, Inc.
Co-director of ATAC project to produce, purify, and test monoclonal antibody heteroconjugates as candidates for human cancer  immunotherapy.  IND for phase I clinicals accepted by FDA.

Research Associate
1981-1987 --St. Jude Children’s Research Hospital,  Biochemistry Dept.
Structure-function studies of calmodulin-dependent enzymes.
Localization of interaction sites of calmodulin for calmodulin-dependent enzymes.

Postdoctoral Fellow of the American Cancer Society
Rockefeller University, Dept. of Developmental and Molecular Biology,  1979-1981
Purified and microsequenced H-2 histocompatability antigens.   Identified, purified, and characterized cell adhesion molecules involved in embryonic development.